Mapk7 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comMapk7 Polyclonal Antibody for Mouse(Mus musculus)

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Mapk7 (Gene name),

Mitogen-activated protein kinase 7 (Protein name ), MK07_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk7(Bmk1;Erk5);

Protein name:

Mitogen-activated protein kinase 7(MAP kinase 7;MAPK 7);

Alternative:

Extracellular signal-regulated kinase 5(ERK-5);Big MAP kinase 1(BMK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MAP2K5 (By similarity). Forms oligomers. Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D.

Function:

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.

Subcellular Location:

Isoform 3 Nucleus Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation.

Protein Attributes:

Sequence length:

806

Sequence:

50:

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300:

350:

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650:

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750:

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806:

PDLQEP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:23939

UniGene:

Mm.38172

Pfam:

PF00069

SMR:

Q9WVS8

String:

Q9WVS8

Uniprot:

Q9WVS8

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ELISA Kit for Mouse MAP kinase 7

Cat.:

E9212h

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96T

ELISA Kit for Mouse MAP kinase 7

Cat.:

E9212m

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ELISA Kit for Mouse MAP kinase 7

Cat.:

E9212r

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ELISA Kit for Mouse MAP kinase 7

Cat.:

E9212b

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96T

CLIA Kit for Mouse MAP kinase 7

Cat.:

U9212m

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Packing:

96T

CLIA Kit for Mouse MAP kinase 7

Cat.:

U9212h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MAP kinase 7

Cat.:

U9212b

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96T

CLIA Kit for Mouse MAP kinase 7

Cat.:

U9212r

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96T

Polyclonal Antibody for Mouse MAP kinase 7

Cat.:

P9212Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 7

Cat.:

P9212Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 7

Cat.:

P9212Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse MAP kinase 7

Protein for Mouse MAP kinase 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus."
Kamakura S. , Moriguchi T. , Nishida E.
J. Biol. Chem.274:26563-26571(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains."
Yan C. , Luo H. , Lee J.-D. , Abe J.-I. , Berk B.C.
J. Biol. Chem.276:10870-10878(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: C57BL/6.
3.

"Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant."
McCaw B.J. , Chow S.Y. , Wong E.S.M. , Tan K.L. , Guo H. , Guy G.R.
Gene345:183-190(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION
strain: C57BL/6.
tissue: Bone marrow.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: NOD.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
strain: C57BL/6J.
tissue: Kidney.
6.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
7.

"Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells."
Dinev D. , Jordan B.W.M. , Neufeld B. , Lee J.-D. , Lindemann D. , Rapp U.R. , Ludwig S.
EMBO Rep.2:829-834(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival."
Dong F. , Gutkind J.S. , Larner A.C.
J. Biol. Chem.276:10811-10816(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure."
Hayashi M. , Kim S.W. , Imanaka-Yoshida K. , Yoshida T. , Abel E.D. , Eliceiri B. , Yang Y. , Ulevitch R.J. , Lee J.D.
J. Clin. Invest.113:1138-1148(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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